The lead grew to 35-0 on a 1-yard touchdown run by Clayton McKinley in the third quarter.
Fourth quarter touchdowns were scored by Taylor Henson (2-yard run) and Zach Mears (95-yard run).
Defensively, the Bulldogs gave up two touchdowns in the fourth quarter, but for three held the Panthers scoreless.
Defense coordinator Tim Hunter credited Colin Brown, Connor Dickey and Cody Reer with solid games. Brown led the team in tackle points (combination of solo and assists) with 18, including four solo. Dickey was second with 10 from his defensive back position.
Ben Wilson and Brandon Wolter each had a pair of tackles for loss, while Seth Williamson recovered a fumble.
"We got some good efforts from a variety of players," Heppner commented. "It is always good to get that first win.
"A lot of people got to play and we stayed relatively healthy ... happy with the effort," he added.
The Bulldogs look to get a little revenge on Friday when they host Milan on Friday. The Indians shutout the Bulldogs 26-0 last season. The game is scheduled to start at 7 p.m.